We are talking about Call of Cthulhu on my discord and I am such a grog when it comes to that game. I have zero interest in running any variant where you have government backing or special powers. You're going to play a law clerk who dies horribly. That's where the fun is! Everything else is pale imitation!
Speaking of pale imitations, I don't really see the point of all the Cthulhu games that aren't Call of Cthulhu. People sure seem to collect them, but they don't seem to actually ever play them. Frankly, Call of Cthulhu just about has that market cornered in ways that its imitators don't even attempt to compete against. System aside, it has a ton of great adventures, and the not-Call of Cthulhus don't. Call of Cthulhu also has some of the best supplements in the role-playing industry, but again, its direct competitors simply do not bring that heat to the table.
Trail of Cthulhu comes the closest to being worthwhile, but even that seems like a game trying to solve a problem (dead-end mysteries) from the wrong side of the issue. Fix that in scenario design, not within the system, you nerds.
My groggiest Call of Cthulhu opinion? I think the 1920s is the best setting for it, hands down.